BreakingtheCostBarrierinBiomanufacturingFebruary2024ByJean-FrançoisBobier,TristanCerisy,Anne-DouceCoulin,CrystalBleecher,VictoriaSassoon,andBrentanAlexanderBreakingtheCostBarrierinBiomanufacturingSincetheUSFDAapprovedthefirstbiosyntheticdrug,insulin,fourdecadesago,themarketforproductscreatedthroughprecisionfer-mentationandbiomanufacturinghasgrownto$100billion.Thesec-tor’ssuccessledtopredictionsthatprecision-fermentedbioproductswoulddisruptindustriesfrompharmaceuticalstofoodtochemicals.Butinareasotherthanpharma—whosebusinessmodelsareParticipantsallalongthevaluechainhaveimportantrolesbuiltonhigh-margin,low-volumeproductswithlowsensitivitytoplay.Mostimmediately,corporatecustomers—thesametocosts—innovationshavecreatedonlynichemarketsincompaniesthatneedtomeetsustainabilityandnetzeroenzymes,fragrances,andfoodandfeedsupplements.pledges—mustdemonstratethatthedemandisrealbycommittingtoofftakeagreementsforfuturedeliveryofThismaybeabouttochange.Demandissolidifyingfornewingredientsandbyadaptingtheirsupplychainsandproductsthatusebiologicalprocessesandgeneticallyproductformulationsaccordingly.Policymakersandregu-modifiedmicroorganismsinplaceoftraditionalproductionlatorscansmooththewaybyofferingincentivesandloanmethods,drivenbytheneedtoachievesustainabilityinguaranteesandremovingredtape.Asdemandfornewmanufacturingwhil...
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